• Bram-Cor Pharmaceutical production - Turnkey plants
  • Bram-Cor turnkey equipment and plants
  • Bram-Cor Pharmaceutical Equipment - Quality by design
  • Bram-Cor Pharmaceutical Equipment - Turnkey Project
  • Bram-Cor Pharmaceutical technologies - turnkey services
  • Bram-Cor Pharmaceutical systems - Training- Human resources management
  • Bram-Cor Pharmaceutical turnkey - projects and services
  • Bram-Cor Technologies - Turnkey Projects and Plants
  • Bram-Cor Pharmaceutical Technologies - Main factory, Parma, Italy - Techinal Dossier

Ilaç Ekipmanları

Paslanmaz çelik işlenmesindeki tecrübemiz ve tutkumuz ayrıntılardaki kaliteyle ilgilenmemize yardımcı olmaktadır. Enerji tasarrufu, hijyen kalitesi ve tüm malzemelerin ve komponentlerin sertifikasyonları ve uzun dönem güvenilirlik bizim ekipmanlarımız için kesin kurallardır.


BRAM-COR engineering team focuses mostly on fluid drugs sterile production processes. A full understanding of the drug production process is the key concept for correct design, born from almost 50 years of experience. Clear definition, assessment, monitoring of critical parameters directly affecting product quality are the baseline for the application of suitable Process Analytical Technologies granting both complete in-line and at-line quality control. Every process follows rigorous cGMP-compliant Standard Operative Procedures. Specification, construction, verification steps within the project lifecycle follow GAMP “V” models, considering Risk Assessment, architecture of system components, functional specification, sanitization, sterilization and validation issues with special overview to a sustainable maintenance of the system. BRAM-COR work breakdown structure consisting in following activities:

  • Design (quality by design)
  • Construction (mechanicals, electro-pneumatics, software)
  • Testing
  • Documentation
  • Installation
  • Validation
  • Start up

 A complete technical documentation is part of our equipment and includes:

  • General Documentation and Constructive Specification
  • Components Documentation
  • Valves Documentation Instruments Documentation
  • Electrical/pneumatic Documentation
  • Hardware and Software Documentation
  • Piping, Fitting and Welding Documentation
  • Non-destructive test certificate
  • Operating and Maintenance Instructions 
  • Spare Parts 

BRAM-COR involves its proven experience in three ranges of pharmaceutical equipment:



BRAM-COR pharmaceutical water treatment systems are designed to produce compendial  

  •     PW - Purified Water
  •     WFI - Water For Injection
  •     PS - Pure Steam


Pre-treatment options, monitoring of critical parameters, regulatory requirement for product quality, consumptions, microbiological control, operation and maintenance requirements, lifecycle costs are key points in our design of all processing steps, from feed water to the point of use. Special care is given to the choice of sanitary materials. Product-contact surfaces are in certified AISI 316L stainless steel, with standard roughness ≤ 0.4 µm. EPDM or PTFE gaskets ensure perfect sealing.  Advanced  Process Analytical Technologies are applied for monitoring issues and professional GAMP compliant automation is provided for system control.



BRAM-COR designs, manufactures and installs complete Formulation & Preparation Plants starting from specific Product and User Requirements. Sterile preparation or cleaning and sterilization of process vessels or contact equipment are common issues in the pharmaceutical industry and therefore a must in any of our projects.

Specific manufacturing of solutions or sanitization & sterilization requirements can be satisfied by our processing systems, providing the optimum balance of performance with cost effective aseptic processing equipment through BRAM-COR solutions including:

Mixing Tanks And Bioreactors

  • Mixing Vessels
  • Pressure Tanks / Pressure Vessels
  • Reactors Vessels
  • Customized Formulation Tanks
  • Mobile Mixing Vessels
  • Atmospheric Transfer Tanks

Cip/Sip Systems

  • Customized Stations
  • Mobile Stations

Ancillary Systems For Formulation Lines

  • Triblenders
  • Filtration Groups
  • Solution Transfer Circuits Through Nitrogen Or Sanitary Pumps
  • Vessels Loading Platforms
  • Laminar Air Flow Cabinets



BRAM-COR pharmaceutical bags or bottles filling equipments are intended for automatic, semiautomatic or manual use, for different bags or plastic/glass bottle sizes, according to various production needs from min. 10 ml, smaller volumes on demand.

Our equipments ensure trouble-free operation, with reduced maintenance costs and long-term reliability. Complete bottle lines are integrated with washing machines, capping and crimping machines, labelling lines  and belt conveyors.

  • Manual, Semiautomatic and Automatic Filling Machines for BAGS
  • BAGS making machines
  • FORM-FILL-SEAL equipment for PP BAGS
  • Visual Inspection lines for BAGS   
  • Machines for assembling Plugs and Connectors for BAGS
  • Filling Machines for BOTTLES
  • Washing, Stoppering, Capping Machines for BOTTLES
  • Complete integrated lines including CIP /SIP skids 


BFIL Linear Filling Machines for Bags

BRAM-COR manufactures bags linear filling equipment. BFIL according to cGMP regulations. The equipment is completely validable with all parts in contact with the fluids in AISI 316L
Tüm Oku

CIP/SIP Sistemleri

BRAM-COR Cleaning in Place / Sterilizing in Place systems are designed to fully meet cGMPs requirements in cleaning and sterilizing practices commonly applied in pharmaceutical process lines.
Tüm Oku

CPSG PS Generators - Saf buhar jeneratörü

BRAM-COR Pure Steam Generators Mod. CPSG produce dry, saturated steam, suitable for sterilization of pharmaceutical production plants, for direct contact with API, ...
Tüm Oku

CROS Ters Ozmoz Sistemleri

CROS Sanitary Reverse Osmosis Systems are designed to produce compendial purified (PW) and higly purified (HPW) water through several water treatment steps,
Tüm Oku

DISS Formülasyon - Karıştırıcıları ve biyoreaktörler

BRAM-COR offers a complete range of preparation lines suitable for any pharmaceutical formulation: reactor vessels, pressure vessels, pressure tanks, mobile mixing vessels, customized formulation tanks,atmospheric transfer tanks.
Tüm Oku

DPSG Single Effect - Tek Etkisi Distile

The BRAM-COR Single Effect Distiller Mod. DPSG is both a Still and a Pure Steam Generator. This equipment produces dry, saturated steam to be used as sterilizing agent.
Tüm Oku

DTS Heat/Cool Eşanjörleri

Double Tube Sheet Heat Exchangers BRAM-COR DTS are designed to maximize the efficency, while minimizing resistance to fluid flow through the exchanger thus increasing the performance.
Tüm Oku

FFIL Doğrusal Dolum Makineleri için şişeler

The FFIL pharmaceutical linear filling machine for bottles represents an evolution of filling for pharmaceutical rigid vessels, combining reliability, precision and low maintenance costs.
Tüm Oku

Formülasyon için aksesuarlar sistemleri

According to specific product requirements (viscosity, temperature, oxygen sensitivity, aseptic issues etc.), BRAM-COR integrates his formulation plants
Tüm Oku

GENO Generator - Ozon Jeneratörü

BRAM-COR full-stainless steel OZONE GENERATORS Mod. GENO are conceived for pharmaceutical application, i.e. for water disinfection and loop sanitization.
Tüm Oku

KOMB Enjeksiyon Için Su + Saf Buhar Jeneratörü

KOMB is a unique equipment for the simultaneous production of WFI and PS, combining the double functions of a MEDistiller and of a Pure Steam Generator
Tüm Oku

LOOP - Dağıtım Sistemleri

BRAM-COR integrates its equipment with state-of-the-art distribution loops. Our Loop design is the result of a careful evaluation of Points of Use delivery criteria.
Tüm Oku

NTOS-NTE-TARO İlaç Konveyörler & Pikap

Bram-Cor customized belt conveyors are designed to satisfy any requirement in the handling of pharmaceutical containers throughout the drug packaging process.
Tüm Oku

PRTW Su Ön Arıtma Sistemleri

BRAM-COR Water Pre-Treatment Systems Mod. PRTW are customized upon a careful evaluation of feed water quality using local water analysis.
Tüm Oku

SCADA Kontrol Sistemi

From equipment control to production line supervision, BRAM-COR SCADA systems (Supervisory Control And Data Acquisition) provide full management control throughout the plant lifecycle.
Tüm Oku

SMPT ME Distillers - Multil-etkisi damıtıcı

BRAM-COR Multiple Effect Stills Mod. SMPT are designed and manufactured according to cGMP to produce compendial Water for Injection.
Tüm Oku

STDA Aksesuar ve Bileşenleri

Special sanitary components in AISI 316L fit pharmaceutical systems and industrial lines, such as 316L SS housings for water and air filters
Tüm Oku

STMC VC Distiller - Mekanik Buhar Sıkıştırmalı

STMC Vapor Compression Distiller produces compendial distilled water for pharmaceutical applications (WFI), such as LVP, SVP,
Tüm Oku

STOC Depolama Tankları

BRAM-COR range of products includes a complete range of pharmaceutical holding tanks for storing compendial.
Tüm Oku

UVITRON UV Reactors - Lambaları ve Kontroller

BRAM-COR produces the Uvitron line, a wide range of UV Reactors and Control Units offering advanced technical features.
Tüm Oku

VIS Görsel Inceleme Hatları

Particulate matter in parenteral solutions can be detected through BRAM-COR VIS Inspection systems with black/white background for human inspection.
Tüm Oku

Yıkama, Örtümü & Tıpalama Sistemleri

As a functional completion to our bottles filling lines, the Capping Machines of Bram-Cor ensure a full-automated sealing operation.
Tüm Oku