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  • Bram-Cor Pharmaceutical Equipment - Processing System
  • Bram-Cor Pharmaceutical Equipment - Water Treatment - Uvitron UV Reactor
  • Bram-Cor Processing Systems - Formulation and preparation for pharmaceutical plants
  • Bram-Cor Pharmaceutical Equipment - Pure Steam Generator - CPSG -Allen Bradley control panel

CROS Reverse Osmosis System

BRAM-COR is committed to providing a clear answer to every need of water treatment to produce pharmaceutical waters (i.e. PW or WFI) or compendial water for other critical applications (cosmetics, healthcare, human food and animal feed, for example). Our approach is really focused, with a wide range of specific knowledge. BRAM-COR CROS Sanitary Reverse Osmosis Systems, in particular, are designed to produce compendial purified (PW) and also Water for Injection (WFI), through several water treatment steps, according to any specific feed water quality and production need.


The treatment steps, necessary to separate the water from organic substances, high and medium molecular weight ions and from bacteria / pyrogenes, may include:

  • Sodium hypochloride dosing station for water disinfection and oxidation of organic substances, reducing the bacterial charge
  • Sodium metabisulphite dosing station for neutralization and chlorine
  • Double filtration system to eliminate solid substances in inlet water
  • Single or double osmotic stage
  • Continous Electro-Deionizer
  • UV lamps
  • Final sterile filtration -0,22 µm

 PW is usually obtained through:

  • Single stage RO + Electrodeionization
  • Double stage RO
  • Double stage RO + Electrodeionization

WFI is usually obtained through an Ultrafiltration (UF) system located downstream.  

In each RO stage, water is processed through thin film composite RO membranes, offering the highest rejection of contaminants.


Two different flows are generated by the RO system: permeate water, corresponding to PW specification, and RO concentrate, which is recycled in the system in order to obtain a higher recovery with a lower consumption of inlet water. An additional devoted RO step might also be added to reduce the amount of concetrate water to be wasted.


BRAM-COR CROS equipment offer range of PERMEATE capacity spanning from 100 up to 20.000 lph, complying with cGMP and FDA regulations, including

  • Centrifugal booster pump in AISI 316L stainless steel, Electronic pressure transducers automatically regulating the pump capacity  
  • AISI 316L stainless steel membrane vessels
  • Sanitary in-line instrumentation to monitor product critical parameters, such as conductivity , temperature and pH.
  • Full automation managed through GAMP-compliant hardware and software
  • Framework and control board in AISI 304 stainless steel satin finished
  • CIP sanitization or HOT WATER sanitization


Techniques such as water softening, descaling, pre filtration, degasification, nanofiltration, electro-deionisation, ozonation, UV treatment and micro-filtration should all be considered, in relation to the feed water quality. Subsequently, the water quality must correspond to the quality levels of the pharmacopoeia required, if it should use, for example, for the production of Water for Injection (infusional bags or bottles, and so on). 

However, producing WFI with Reverse Osmosis systems requires special attention, unless the feed water is really excellent, since in RO there is not a water changing state (from liquid to vapor, that is a natural microbiological barrier). With the availability of more technologically advanced membranes UF, we can get cold WFI. So, the WFI meets all the parameters required (USP, EP, JP, …). Our RO Systems + UF achieve an optimal WFI quality; however, once in production, any RO system requires a continuous control on its efficiency, in terms of membrane degradation, biofilm prevention  and microbial charges, with periodic sanitization and validation. If there are no obstacles in ensuring this constant monitoring, which must also concern distribution loops, the reverse osmosis system can offer a real and meaningful advantage, reducing the energy needs and thus reducing production costs.